Phase Ib/II study of hydroxychloroquine in combination with chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC).
Identifieur interne : 000542 ( Main/Exploration ); précédent : 000541; suivant : 000543Phase Ib/II study of hydroxychloroquine in combination with chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC).
Auteurs : Jyoti Malhotra [États-Unis] ; Salma Jabbour [États-Unis] ; Michelle Orlick [États-Unis] ; Gregory Riedlinger [États-Unis] ; Yanxiang Guo [États-Unis] ; Eileen White [États-Unis] ; Joseph Aisner [États-Unis]Source :
- Cancer treatment and research communications [ 2468-2942 ] ; 2019.
Abstract
Activation of cell survival pathways such as autophagy represents a potential resistance mechanism to chemotherapy in NSCLC. Preclinical studies report that autophagy inhibition suppresses lung tumor development and progression. We report the safety and efficacy for adding autophagy inhibitor, hydroxychloroquine, to chemotherapy in a phase Ib/II single-arm study in patients with metastatic NSCLC.
DOI: 10.1016/j.ctarc.2019.100158
PubMed: 31521049
Affiliations:
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Preclinical studies report that autophagy inhibition suppresses lung tumor development and progression. We report the safety and efficacy for adding autophagy inhibitor, hydroxychloroquine, to chemotherapy in a phase Ib/II single-arm study in patients with metastatic NSCLC.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>New Jersey</li></region></list><tree><country name="États-Unis"><region name="New Jersey"><name sortKey="Malhotra, Jyoti" sort="Malhotra, Jyoti" uniqKey="Malhotra J" first="Jyoti" last="Malhotra">Jyoti Malhotra</name></region><name sortKey="Aisner, Joseph" sort="Aisner, Joseph" uniqKey="Aisner J" first="Joseph" last="Aisner">Joseph Aisner</name><name sortKey="Guo, Yanxiang" sort="Guo, Yanxiang" uniqKey="Guo Y" first="Yanxiang" last="Guo">Yanxiang Guo</name><name sortKey="Jabbour, Salma" sort="Jabbour, Salma" uniqKey="Jabbour S" first="Salma" last="Jabbour">Salma Jabbour</name><name sortKey="Orlick, Michelle" sort="Orlick, Michelle" uniqKey="Orlick M" first="Michelle" last="Orlick">Michelle Orlick</name><name sortKey="Riedlinger, Gregory" sort="Riedlinger, Gregory" uniqKey="Riedlinger G" first="Gregory" last="Riedlinger">Gregory Riedlinger</name><name sortKey="White, Eileen" sort="White, Eileen" uniqKey="White E" first="Eileen" last="White">Eileen White</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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